TY - T1的雾化rhDNase在囊性纤维化:影响白细胞蛋白酶在痰JF -欧洲呼吸杂志》乔和J SP - 2200 LP - 2206欧元六世- 9 - 11盟装置T非盟-帕斯托雷,FD盟——Schlegel-Haueter SE AU - Filthuth,我非盟——Auckenthaler, R AU -瑞塔,D AU -苏特尔Y1 - 1996/11/01 UR - //www.qdcxjkg.com/content/9/11/2200.abstract N2 -在囊性纤维化(CF),大量的免费的白细胞蛋白酶存在于支气管分泌物,导致进步的肺损伤。重组、人类脱氧核糖核酸酶(rhDNase)是一种新型的治疗,减少痰液粘度。然而,脱氧核糖核酸酶已被证明,在体外,释放阳离子酶复合物与脱氧核糖核酸(DNA)。本研究进行了评估这种影响体内。免费人白细胞弹性蛋白酶(对待),人类白细胞组织蛋白酶G (HCG),总趋化现象的活动,和interleukin-8(引发)测定痰从8个病人之前,期间和之后rhDNase治疗。After 15 days of treatment, HLE activity increased by 81+/-44% (NS), and HCG by 189+/-70% (p<0.05). One week after stopping a 4-6 months treatment, HLE activity decreased by 35+/-18% (p<0.05), and HCG by 43+/-11% (p<0.05). Sputum bacterial density, chemotactic activity, and IL-8 concentration did not change. Thus, treatment with rhDNase can indeed increase the activity of HLE and HCG in the bronchial secretions of CF patients, and this effect is still detectable after several months of treatment. If this can be shown to be clinically relevant, combination therapy of recombinant human deoxyribonuclease with protease inhibitors should be considered as an approach to the problem. ER -