Ty-jour t1 - 哮喘和健康受试者的异丙蛋白化杂化期间和后杂交间隙的变化JF - 欧洲呼吸杂志Jo - Eur Respir J SP - 742 LP - 751 VL - 8是 - 5 Au - Daviskas,E Au - Anderson,SD AU - Gonda,I Au - Chan,HK Au - Cook,P Au - Fulton,R Y1 - 1995/05/01 UR - //www.qdcxjkg.com/content/8/5/742.abstract n2- 由于蒸发水分损失,具有干燥空气的Hyperpnoea可能导致PericiLiry流体层(PFL)的深度和高摩尔度降低。我们调查了粘蛋白清除(MCC)是否可能受干燥空气HyperPnoea的影响,这也导致哮喘患者的气道缩小。MCC通过放射性溶解技术测量,约1小时,在3个单独的日子中的10个哮喘和8个健康受试者中:1)鼻腔静息与环境空气;2)具有干燥空气的异映癌过度通气剂(ISH);和3)含有温暖的空气。对整个右肺的初始和干预后肺放射性的分析表明,与湿润空气和鼻静呼吸的ISH相比,MCC在ish后的含量下降和增加两组的整个右肺。间隙的平均降低(+/- 95%置信区间(95%CI))为-9.3%(-3.1至-15.6%)和-3.6%(-2.0至-9.1%),平均增加(+/ - 9.5%CI)分别为19.2%(11.8至26.6%)和14.8%(7.1%至22.5%),与哮喘和健康受试者分别为温暖的潮湿空气。 However, regional analysis showed that the changes were present in all lung regions of the asthmatics, whilst only in the central region of the healthy subjects. The duration of the increased clearance rates post-ISH was also different in both groups. The changes in mucociliary clearance during and after isocapnic hyperventilation with dry air was probably related to the water content of the inspired air, causing transient changes in the periciliary fluid layer. ER -