TY -的T1 -鼻持续气道正压与同时代的睡眠补充氧气apnoea-hypopnoea综合症和严重的慢性阻塞性肺疾病JF -欧洲呼吸杂志》乔和J SP - 111 LP - 116欧元六世- 9 - 1 AU Sampol G AU -加尔,太盟-罗卡,非盟- de la公路,MD盟——Bofill JM盟——莫雷尔,F Y1 - 1996/01/01 UR - //www.qdcxjkg.com/content/9/1/111.abstract N2 -我们的研究的目的是评估的应用鼻持续正压通气(nCPAP)补充氧气的校正上呼吸道阻塞性睡眠和低氧血稳定睡眠apnoea-hypopnoea综合症患者(sah)和严重的慢性阻塞性肺疾病(COPD)。Ten male patients with symptomatic SAHS and severe COPD (forced expiratory volume in one second < 50% of predicted) were studied for three consecutive nights. Diagnostic polysomnography was performed the first night and repeated with increasing nCPAP levels, with and without supplemental oxygen on the second and third nights, respectively. Diagnostic polysomnography showed: mean (SD) apnoea-hypopnoea index 41 (22) events.h-1; mean arterial oxygen saturation (Sa,O2) was 86 (2)% and mean desaturation nadir was 81 (4)% during non-rapid eye movement (nREM) sleep and 80 (7)% and 73 (9)%, respectively during REM sleep. The application of nCPAP during the second night corrected apnoeas and hypopnoeas, but mean Sa,O2 remained < 90% in all patients. With the addition of oxygen at a flow of 1.5 L.min-1 at suboptimal nCPAP levels, we observed an increase in apnoea frequency, persistence of apnoeas at nCPAP levels which eliminated them when no supplemental oxygen was administered, and longer duration of apnoeas and hypopnoeas. However, when the effective nCPAP level of the second night was reached with supplemental oxygen during the third night, its efficacy in eliminating apnoeas and hypopnoeas was maintained and, furthermore, all patients presented Sa,O2 > 90%, with no greater hypercapnia cardiac arrhythmias. We conclude that nasal continuous positive airway pressure with supplemental oxygen constitutes a practical therapeutic alternative for hypoxic patients with sleep apnoea-hypopnoea syndrome and chronic obstructive pulmonary disease. ER -