TY -的T1 -氧饱和度在慢性阻塞性肺疾病的日常活动期间摩根富林明-欧洲呼吸杂志》乔和J SP - 2584 LP - 2589欧元六世- 9 - 12个盟Soguel Schenkel, N盟——Burdet L AU - de Muralt B非盟-拟合,慢性阻塞性肺疾病(COPD)患者常因肺泡通气不足、通气灌注不匹配加重、有时伴有阻塞性睡眠呼吸暂停而发生夜间氧破坏。相比之下，人们对它们在日常生活中各种活动中的氧状态知之甚少。本研究的目的是比较昼夜氧饱和度，并评估不同日常活动对COPD患者的影响。在一项康复计划中，我们研究了30例中度至重度COPD患者(1秒中位用力呼气量(FEV1)为预测的37%)，无明显低氧血症(中位动脉氧张力(Pa,O2) 9.1 kPa)。采用脉搏血氧仪测定夜间(8 h)和白天(10.5 h)的动脉血氧饱和度(Sa、O2)，计算Sa、O2的平均值和最小值，去饱和度定义为Sa、O2下降>.h-1 4%。患者的日常活动包括休息、进食、清洗、雾化治疗和行走。平均Sa,O2在夜间(88%)低于白天(89%)。相比之下，最小的Sa和O2白天(69%)比夜间(72%)更低，而且白天的去饱和次数(8.6去饱和.h-1)比夜间(6.8去饱和.h-1)更高。 Mean Sa,O2 was 88% during walking, which was lower than during resting (90%), nebulization (90%), and meals (89%). The number of desaturations was higher during walking (13.1 desaturations.h-1), washing (12.6 desaturations.h-1), and eating (9.2 desaturations.h-1) than during resting (5.3 desaturations.h-1). We conclude that daily activities, such as walking, washing and eating, are associated with transient oxygen desaturation in patients with moderate-to-severe chronic obstructive pulmonary disease, even without marked resting hypoxaemia. ER -