TY - JOUR T1 -半胸放疗或联合阿霉素、环磷酰胺治疗胸膜间皮瘤47例疗效观察JF - European Respiratory Journal JO - Eur Respir J SP - 2565 LP - 2572 VL - 9 IS - 12 AU - Linden, CJ AU - Mercke, C AU - Albrechtsson, U AU - Johansson, L AU - Ewers，某人Y1 - 1996/12/01 UR - //www.qdcxjkg.com/content/9/12/2565.abstract N2 -为了评估价值的放疗治疗胸膜间皮瘤能够,我们研究肿瘤反应和生存后半胸辐照(RT),或放疗结合阿霉素和环磷酰胺化疗(RTCT)。47例胸膜间皮瘤患者接受8 MV(兆伏特)光子照射病变半胸，总剂量为40戈瑞，每日20 Gy，每周5天。放疗后1个月，患者年龄及lt;或= 70岁，治疗状态良好，给予阿霉素30mg辅助化疗(CT)。第1天和第8天m-2体表，联合环磷酰胺600 mg。m-2，每21天为一个周期。在放疗和/或CT前和术后1个月通过计算机轴位断层扫描(CAT)评估肿瘤反应。在47例(95%可信区间(95% CI)-0.6-13%)照射的肿瘤中，只有3例(PR)有部分缓解。在31例单纯放疗患者中，观察到1例PR;而联合治疗组16例PR中有2例对阿霉素和环磷酰胺联合CT仅诱导了2例PR (95% CI -3.4-28.4%)，联合放疗联合CT诱导了2例PR (95% CI -3.4-28.4%)。 The median survival following the initiation of RT was 7 months in all patients (n = 47), 6 months in the RT group (n = 31), and 13 months in the combined RTCT group (n = 16). Chest pain, performance status and body weight were not favourably affected by the radiotherapy. We conclude that hemithorax irradiation of pleural mesotheliomas with a moderately high dose is not useful, since it produces no improvement in chest pain, few objective tumour responses and no prolongation of survival. ER -