TY - JOUR T1 -哮喘儿童和囊性纤维化患者气道一氧化氮JF -欧洲呼吸杂志JO - Eur Respir J SP - 2537 LP - 2540 DO - 10.1183/09031936.96.09122537 VL - 9 IS - 12 AU - Dotsch, J AU - Demirakca, S AU - Terbrack, HG AU - Huls, G AU - Rascher, W AU - Kuhl，PG Y1 - 1996/12/01 UR - //www.qdcxjkg.com/content/9/12/2537.abstract N2 -我们评估了哮喘和囊性纤维化对呼吸道一氧化氮(NO)浓度的影响。研究了90例哮喘患者(4-14岁)、67例囊性纤维化(CF)患者(5-32岁)和68例对照组(4-34岁)的口腔呼出空气和鼻腔气体样本中的NO水平。化学发光法测定的NO浓度与患者肺活量、1秒用力呼气量(FEV1)和特异性气道阻力相关。在所有组中，口腔呼出空气中的NO浓度与吸入的环境NO相关(r = 0.85-0.91)。在环境NO浓度为0 ppb时，哮喘患者呼出的NO浓度高于囊性纤维化患者和对照组(8.0 +/- 6.1 ppb (n = 33);4.9±2.6 PPB (n = 23);3.0 +/- 2.5 PPB (n = 37);分别;p & lt; 0.001). Similar results were obtained for ventilation-adjusted orally-exhaled NO. Nasal NO concentrations were lower in patients with CF (23 +/- 17 ppb) than in controls and asthmatics (96 +/- 47 and 103 +/- 64 ppb; p < 0.001). There was no relationship between nasal or oral NO and pulmonary function tests. Our results suggest that ambient NO levels influence NO concentrations in orally-exhaled air. Like adults, asthmatic children exhale more NO than their controls. Reduced nasal NO concentrations in patients with cystic fibrosis may reflect chronic epithelial cell damage or an increased mucosal barrier impeding NO diffusion into the airway. ER -