TY - T1的呼气流量限制在机械通风受迫振动法检测到的JF -欧洲呼吸杂志》乔和J SP - 779 LP - 786欧元六世- 9 - 4盟Vassiliou M盟——Peslin R盟——Saunier C盟——DuvivierC Y1 - 1996/04/01 UR - //www.qdcxjkg.com/content/9/4/779.abstract N2 -我们曾观察到呼吸机械阻抗大形势的变化在慢性阻塞性肺疾病(COPD)患者急性呼吸衰竭机械通气,并假定他们由于呼气流量限制(英语)。本研究的目的是在实验上验证这一假设，并评估机械通气中EFL的自动和无创检测的阻抗值。进行了如下研究:1)在机械模拟中，包括一个限流元件;2) 8只麻醉和瘫痪的兔子，在组胺注射之前和期间。在这两种情况下，EFL都是通过降低呼气压力，使用计算机控制的呼吸机来获得;当呼气压力进一步降低时，血流增加的缺失被认为是EFL的证据。通过在气道开口处施加15hz的振荡来测量阻抗。在吸气和呼气阶段分别测量其真实(Re)和虚(Im)部分，其差异与平均吸气模量有关。与类似物一样，EFL在呼气期伴有Re和Im的大幅降低。 In the rabbits, phasic variations of Re were variable in sign and were not significantly different with and without EFL. In contrast, EFL systematically and specifically decreased Im during the expiratory phase. A threshold of -50% provided a sensitivity of 96% and a specificity of 100% for detecting EFL. The observed phasic variations may be explained by airway wall shunt properties. The study suggests that a large decrease of the imaginary part of impedance during the expiratory phase is a sensitive and specific index of expiratory flow limitation during artificial ventilation. ER -