RT期刊文章SR电子T1在机械通气期间通过强制振荡法检测到的机械通气过程JF欧洲呼吸杂志JO EUR呼吸JF欧洲呼吸社会SP 779 OP 786 vo 9 IS 4 A1 Vassiliou，M A1 Peslin，R A1 Saunier，C188bet官网地址A1 Duvivier，C YR 1996 UL //www.qdcxjkg.com/content/9/4/779.Abstract AB，我们以前已经观察到慢性阻塞性肺病（COPD）患者机械性易位的呼吸机械阻抗的大质量变化对于急性呼吸衰竭，并假定它们是由于呼气流量限制（EFL）。这项研究的目的是通过实验测试该假设，并评估机械通气过程中EFL自动和无创检测的阻抗值。进行了研究：1）在机械类似物中，包括流量限制元件；2）在组胺输注之前和期间，在八个麻醉和瘫痪的兔子中。在这两种情况下，使用计算机控制的呼吸机通过降低呼气压力来获得EFL。当进一步降低呼气压力时，没有流量增加作为EFL的证据。通过在气道开口上应用15 Hz振荡来测量阻抗。它的真实（RE）和虚构（IM）部分是在灵感和呼气阶段分别测量的，它们的差异与平均灵感模量有关。 With the analogue, EFL was accompanied by large decreases both of Re and Im during the expiratory phase. In the rabbits, phasic variations of Re were variable in sign and were not significantly different with and without EFL. In contrast, EFL systematically and specifically decreased Im during the expiratory phase. A threshold of -50% provided a sensitivity of 96% and a specificity of 100% for detecting EFL. The observed phasic variations may be explained by airway wall shunt properties. The study suggests that a large decrease of the imaginary part of impedance during the expiratory phase is a sensitive and specific index of expiratory flow limitation during artificial ventilation.