作者@article {Williamson590 ={威廉姆森,IJand Matusiewicz, SP and Brown, PH and Greening, AP and Crompton, GK}, title = {Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations}, volume = {8}, number = {4}, pages = {590--592}, year = {1995}, publisher = {European Respiratory Society}, abstract = {The aim of the study was to assess the prevalence of throat and voice symptoms in asthma patients using pressurized aerosol, metered-dose, inhaled corticosteroid preparations. A questionnaire was administered to hospital out-patients in an asthma clinic and to a control group attending a diabetic clinic. Two hundred and fifty five consecutive out-patients using pressurized aerosol inhaled corticosteroids and 100 controls were surveyed. One hundred and forty seven (58\%) patients taking inhaled steroids reported voice dysphonia or throat symptoms compared with 13\% of control patients. Women admitted to symptoms more frequently than men. Throat symptoms were more prevalent in patients using higher doses of inhaled steroid. Aerosol inhaler-induced cough was reported by 87 (34\%) patients. Local side-effects were equally prevalent both with beclomethasone dipropionate and budesonide aerosol inhalers. The use of a large volume spacing device with either steroid aerosol did not appear to protect against these symptoms. Local side-effects are common in asthmatics taking pressurized aerosol, metered-dose, inhaled steroids.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/8/4/590}, eprint = {//www.qdcxjkg.com/content/8/4/590.full.pdf}, journal = {European Respiratory Journal} }