TY -的T1 Lazaroid u - 74389 F变弱佛波醇ester-induced肺损伤在兔子JF -欧洲呼吸杂志》乔-欧元和J SP - 758 LP - 764 - 10.1183 / 09031936.96.09040758六世- 9 - 4非盟- M Miniati AU - F球菌盟蒙蒂AU - E菲利皮主持获奖者盟盟- R - M Ferdeghini盟V Gattai AU - M Pistolesi Y1 - 1996/04/01 UR - //www.qdcxjkg.com/content/9/4/758.abstract N2 -我们检查抗氧化的效果Lazaroid u - 74389 F十四烷酸对兔急性肺损伤诱导由佛波醇酯(PMA)。三十分钟后收到u - 74389 f(15毫克。公斤增长值)或u - 74389 f,兔子(n = 60)给出了PMA(60微克。公斤注射)。PMA车辆注入兔子(n = 20)作为控制。5 h段PMA或PMA车辆注射后,我们测量动脉pH值,动脉氧张力(Pa, O2),动脉二氧化碳张力(Pa,二氧化碳)和血浆浓度的中性粒细胞化学引诱物interleukin-8(引发)。在后期,肺是宏观损伤和检查组织学检查。在肺组织丙二醛含量化验指标的脂质过氧化作用。在支气管肺泡灌洗(BAL)和微分活菌数,总蛋白质和引发浓度测定。与正常对照组相比,兔子的挑战与单独PMA发达动脉酸中毒、高碳酸血症和低氧血,伴随着在等离子体引发浓度显著上升。u - 74389 f预防动物未出现明显的异常动脉血气在等离子体引发浓度明显降低。 U-74389F did not prevent PMA-induced lipid peroxidation. However, macroscopic signs of lung injury and the degree of alveolar haemorrhage and protein extravasation were significantly less severe in pretreated rabbits than in those given PMA alone. In addition, U-74389F significantly reduced IL-8 concentration and neutrophil number in BAL. By histological assessment, 80% of lung neutrophils were localized in alveolar spaces of animals receiving PMA alone. Conversely, in U-74389F pretreated animals, 75% of neutrophils were distributed within extra-alveolar blood vessels and alveolar septa. We conclude that lazaroid U-74389F attenuates lung injury in rabbits given PMA by preventing neutrophil migration into pulmonary alveoli. This effect may, in part, be related to downregulation of IL-8 production. ER -