TY - JOUR T1 -阻塞性睡眠呼吸暂停和重叠综合征患者的呼吸控制JF -欧洲呼吸杂志JO - Eur Respir J SP - 542 LP - 545 VL - 8 IS - 4 AU - Radwan, L AU - Maszczyk, Z AU - Koziorowski, A AU - Koziej, M AU - Cieslicki, J AU - Sliwinski, P AU - Zielinski慢性阻塞性肺疾病(COPD)和呼吸衰竭可合并阻塞性睡眠呼吸暂停(OSA);所谓的“重叠综合症”。在CO2刺激过程中，阻塞性、高碳酸血症患者的通气和口腔阻塞压力反应均变钝。本研究的目的是比较OSA患者和重叠综合征患者的呼吸模式和CO2反应。研究对象包括20名患有阻塞性睡眠呼吸暂停(OSA)但肺功能正常的肥胖男性(A组)，11名患有重叠综合征的肥胖男性(B组)和13名健康的非肥胖受试者(C组)。研究了肺功能测试、呼吸模式、静息时的口咬合压力(P0.2)以及CO2再呼吸时的呼吸反应。采用标准多导睡眠描记法诊断阻塞性睡眠呼吸暂停。A组与B组在呼吸暂停及呼吸暂停方面差异无统计学意义。睡眠时的低通气指数(62 vs 54)，平均动脉氧饱和度(SaO2) (85 vs 84%)，身体质量指数(BMI) 34.3 vs 36.3 kg.m-2。 Minute ventilation, mean inspiratory flow and P0.2 at rest were increased in both groups of patients in comparison to controls. During CO2 rebreathing, group A had normal ventilatory and P0.2 responses, similar to controls, (2.7 +/- 1.1 vs 2.1 +/- 0.4 l.min-1.mmHg-1 and 0.7 +/- 0.3 vs 0.71 +/- 0.25 cmH2O.mmHg-1, respectively). However, Group B had significantly decreased ventilatory and P0.2 responses to CO2 (0.71 +/- 0.23 l.min-1.mmHg-1 and 0.34 +/- 0.17 cmH2O.mmHg-1, respectively). This comparison showed that patients with OSA had normal CO2 response when awake, whereas those with overlap syndrome had diminished CO2 response when awake.(ABSTRACT TRUNCATED AT 250 WORDS) ER -