JF - European Respiratory Journal JO - Eur Respir J SP - 537 LP - 541 VL - 8 IS - 4 AU - Laks, L AU - Lehrhaft, B AU - Grunstein, RR AU - Sullivan,研究睡眠障碍性呼吸中肺动脉高压的发生频率及相关因素。测定了100例阻塞性睡眠呼吸暂停(OSA)患者的肺功能和动脉血气(RDI)。20 episodes.h-1)。26例患者有明显的慢性气流受限(CAL)。总体而言,42%的患者清醒时肺动脉压>20毫米汞柱。肺动脉高压患者年龄更大,动脉血二氧化碳压(PaCO2)更高,动脉血氧压(PaO2)更低,1秒用力呼气量(FEV1)更低。Pao2、PaCO2、FEV1与肺动脉压力相关(相关系数r2分别为0.50、0.46、0.49)。这三个因素结合起来可以解释33%的肺动脉压力变异性。 Six patients had pulmonary hypertension despite a PaO2 in excess of 10.7 kPa (80 mmHg). We conclude that pulmonary hypertension is common in patients with moderate and severe sleep apnoea, especially those with coexisting chronic airflow limitation. The presence of daytime hypoxaemia is not a prerequisite in the development of pulmonary hypertension in these patients. ER -