作者@article {Bisgaard856 = {Bisgaard H},乳头le = {A metal aerosol holding chamber devised for young children with asthma}, volume = {8}, number = {5}, pages = {856--860}, year = {1995}, publisher = {European Respiratory Society}, abstract = {The low tidal volume and flow in preschool children may reduce the efficiency of aerosol delivery from a pressurized metered-dose inhaler (pMDI) through a traditional holding chamber. A prototype small-volume steel holding chamber with two one-way valves was devised to prolong aerosol availability in the chamber and to ensure unidirectional airflow. Dead space between the valves was minimized to less than 2 ml. The dose-delivery and rate of passive disappearance of a budesonide pMDI aerosol were compared between this prototype and the large-volume, single-valved plastic Nebuhaler, in 164 asthmatic children less than 8 yrs of age. In vitro, the half life of aerosol disappearance in the steel prototype and the plastic Nebuhaler was \> 30 s and 9 s, respectively. In vivo, the prototype delivered an age-independent mean dose of 38\% of the nominal dose, and the Nebuhaler delivered an age-dependent mean dose, ranging from 42\% of the nominal dose in children \> or = 4 yrs to 19\% of the nominal dose in infants. We conclude that the use of plastic for holding chambers may influence dose-delivery, and single-valve control may cause age-dependent dose-delivery. Reproducible age-independent drug-delivery may be achieved by pMDI aerosol inhaled through a small-volume metal holding chamber with separate inlet and outlet valves and minimized dead space. This holding chamber would improve the possibilities of aerosol therapy for young children.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/8/5/856}, eprint = {//www.qdcxjkg.com/content/8/5/856.full.pdf}, journal = {European Respiratory Journal} }