％0期刊文章％a lude，ea a bee，d％a crambes，o％a霍华德，p％t抗呼吸和抗凝集性收缩动作在豚鼠中的fenspiride动作％d 1995％j欧洲呼吸杂志％j欧洲呼吸杂志％p 1699999-1704％V 8％N 10％X Fenspiride是一种非甾体类抗炎剂，我们先前已证明它在豚鼠中具有体内抗抗浓缩收缩剂的作用。我们目前已经使用收缩物P，Neurokinin A，柠檬酸和辣椒素在麻醉的豚鼠中研究了这一动作。据报道，芬斯螺旋体可在患者的咳嗽中产生主观改善。我们已经使用有意识的咳嗽模型作为一种更明确的方法来研究芬梭对辣椒素和柠檬酸诱导的咳嗽的影响。烟雾化的芬螺旋（1 mg.ml-1）导致辣椒素诱导的支气管收缩的58％逆转；和i.v.Fenspiride（1mg.kg-1）45％柠檬酸诱导的支气管收缩。物质P-和Neurokinin A诱导的支气管收缩不受1 mg.kg-1 i.v.的影响。Fenspiride。燃气的芬螺旋（1、3和10 mg.ml-1）施用4分钟，降低了柠檬酸（300 mM）诱导的咳嗽，但0.1 mg.ml-1无效。 Pretreatment with aerosolized fenspiride (10 mg.mL-1) caused a shift in the citric acid dose response curve to the right. For citric acid-induced cough, the duration of action of aerosolized fenspiride (10 mg.mL-1) was found to be 5 and 15 min post-treatment. Aerosolized capsaicin (30 microM) induced cough was also reduced by 3 and 10 mg.mL-1 aerosolized fenspiride, but no significant effect was found with 1 mg.mL-1. We conclude that aerosolized fenspiride reduces capsaicin- and citric acid-induced bronchoconstriction as well as induced cough in guinea-pigs in vivo. Whether a pathway common to both cough and bronchoconstriction is the site of action of fenspiride remains to be established. We postulate that fenspiride, acting as an antitussive and antibronchoconstrictor agent, would be beneficial in the clinical situation for those patients with hyperresponsive airways. %U //www.qdcxjkg.com/content/erj/8/10/1699.full.pdf