TY - JOUR T1 -吸入蒸馏水后对methacholine敏感性的变化:JF - European Respiratory Journal JO - Eur Respir J SP - 253 LP - 256 VL - 8 IS - 2 AU - Kivity, S AU - Poterman, R AU - Schwarz, Y AU - Soferman, R AU - Topilsky，在哮喘患者中，吸入蒸馏水可引起支气管收缩和对乙酰胆碱敏感性的短暂增加。本研究的目的是确定诱导支气管收缩在蒸馏水刺激后对甲胆碱敏感性增加中的作用。18名哮喘儿童(9-17岁)吸入蒸馏水后受到刺激。在吸入蒸馏水前、1.5小时和24小时后测定支气管反应性，即刺激浓度的methacholine使强迫呼气量在一秒内减少20% (PC20)。吸入蒸馏水后，8例患者(组I)第1次FEV1下降超过15%(平均23%);然而，在其余10例(第二组)中，下降小于7%(平均1%)。PC20对甲胆碱的几何平均值和95%置信区间(CI)仅在吸入蒸馏水后1.5小时短暂下降。从0.78毫克下降。ml-1 (95% CI 0.11-5.54 mg.ml-1) at baseline to 0.25 mg.ml-1 (95% CI 0.03-2.14 mg.ml-1) after challenge in Group I; and from 2.67 mg.ml-1 (95% CI 0.35-20.34 mg.ml-1) at baseline to 0.72 mg.ml-1 (95% CI 0.18-14.87 mg.ml-1) after challenge in Group II. The transient increase in sensitivity to methacholine observed following inhalation of distilled water occurred independently of the bronchoconstrictive response. This finding may have important clinical implications when hypo-osmolar solutions are used for delivery of drugs. ER -