PT -期刊文章盟Hedner J盟——Darpo B非盟- Ejnell H AU -卡尔森,J盟——Caidahl K TI -减少交感神经活动在睡眠呼吸暂停长期CPAP治疗后:心血管影响援助- 10.1183 / 09031936.95.08020222 DP - 1995年2月01 TA -欧洲呼吸杂志》第六PG - 222 - 229 - 8 //www.qdcxjkg.com/content/8/2/222.short的IP - 2 4099 - 4100 - //www.qdcxjkg.com/content/8/2/222.full所以欧元和J1995 2月01;8 AB - 12例严重阻塞性睡眠呼吸暂停患者纳入一项开放、长期、前瞻性随访研究，探讨鼻持续气道正压(CPAP)对交感神经活动、心脏结构和血压的影响。在CPAP进行平均20.5个月(14-26个月)前后，评估血浆去甲肾上腺素(P-NE)(白天休息时)、昼夜尿NE (U-NE)、凡尼扁豆酸和甲肾上腺素，以及24小时无创血压(BP)记录和多普勒超声心动图。平均自我报告使用CPAP的时间为卧床时间的89%(范围65-100%)。静息日P-NE范围为0.35-0.83 ng。与健康对照组相比，Ml-1水平升高。只有夜间U-NE、日间平均血压和24小时平均血压与OSA严重程度相关。夜间肾上腺素与昼夜舒张及夜间收缩压有关。基线左心室质量指数(LVMI)与日间收缩压和P-NE相关。长期CPAP治疗可降低交感神经活动的生化指标。 P-NE decreased by approximately 50%, and daytime and night-time vanylmandelic acid and metanephrine by 32-54%. In contrast, there were no overall reductions in BP or LVMI. It is concluded that obstructive sleep apnoea is associated with high sympathetic activity both during sleep and waking periods. Urinary metanephrine excretion seemed to reflect blood pressure, but neither daytime nor night-time catecholamine excretion was directly related to disease severity in patients with severe obstructive sleep apnoea.(ABSTRACT TRUNCATED AT 250 WORDS)