作者@article {Vos74 = {Vos, PJ福杰尔,HT and van Herwaarden, CL}, title = {Predictors for nocturnal hypoxaemia (mean SaO2 < 90\%) in normoxic and mildly hypoxic patients with COPD}, volume = {8}, number = {1}, pages = {74--77}, year = {1995}, publisher = {European Respiratory Society}, abstract = {Detection of nocturnal hypoxaemia, defined as a mean arterial oxygen saturation below 90\%, in normoxic or mildly hypoxic chronic obstructive pulmonary disease (COPD) patients seems clinically relevant, since this feature may precede pulmonary hypertension. Nocturnal studies are expensive and time-consuming procedures. The current study investigates to what extent it is possible to predict nocturnal hypoxaemia from daytime parameters. Forty two COPD patients with a daytime arterial oxygen tension (PaO2) above 8 kPa participated. Nocturnal oxygenation, daytime blood gas values, and ventilatory responses to hypercapnia were measured. In 10 patients, enough desaturations occurred to qualify as nocturnal hypoxaemia. They had a significantly lower daytime PaO2 value, and a lower steady-state hypercapnic ventilatory response. They also smoked more often, and complained about daytime sleepiness. Multiple linear regression analysis demonstrated that daytime PaO2 (32\%) was the best independent predictor. Sleepiness (12\%), and number of cigarettes smoked (5\%) also contributed independently, but in a minor way. Patients with a high daytime PaO2 (\> 11 kPa) did not develop nocturnal hypoxaemia. The hypercapnic ventilatory response was used to distinguish nocturnal hypoxaemic from normoxaemic patients. Only patients with a low response (\< 3.5 l.min-1.kPa-1) appeared to run a risk of developing nocturnal hypoxaemia. The sensitivity of this test was 80\%, and the specificity 70\%. It is concluded that daytime PaO2, hypercapnic ventilatory response and sleepiness are helpful in predicting nocturnal hypoxaemia.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/8/1/74}, eprint = {//www.qdcxjkg.com/content/8/1/74.full.pdf}, journal = {European Respiratory Journal} }