％0期刊文章％a marquette，ch％a stach，b％a cardot，e％a bervar，jf％saulnier，f％a lafitte，jj％a goldstein，p％a wallaert，b％a tonnel，ab％t高剂量和低剂量全身性皮质类固醇在急性严重哮喘％D 1995％J欧洲呼吸期份％p 22-27％v 8％n 1％x急性严重严重的全身性皮质类固醇中哮喘仍然是一个尚未解决的问题。在这项双盲，随机研究中，我们比较了两剂甲基泼尼松龙（1 vs 6 mg.kg-1 Q.D.时期。并发疗法，包括氧，吸入和静脉内的沙丁胺醇和氨基氨叶素。通过串行床边肺活量测定法评估了反应。在24和44 h时，在一秒钟（FEV1）（FEV1）（FEV1）（表示为预测值的百分比）的主要结果测量值。该试验的目的是为了实现90％的统计能力。低剂量组纳入了23例患者，高剂量组中包括24例。 Both groups were comparable in terms of demographic profiles, history of asthma, and severity of the current attack. Improvement in pulmonary function was similar in both groups. At 44 h, the mean (+/- SD) FEV1 values were 53 +/- 22 and 45 +/- 14% in the low and in the high-dose group respectively (NS). We conclude that high dose systemic corticosteroids offer no further benefit over low-doses in the treatment of severe acute asthma. %U //www.qdcxjkg.com/content/erj/8/1/22.full.pdf