PT-期刊文章Au -Johnson，Pr au -Black，Jl au -Armor，Cl Ti-人类孤立的支气管DP的血小板激活因子诱导的收缩 - 1992年9月1日TA-欧洲呼吸杂志PG -970--974 VI-5 IP -8 4099 -http：//www.qdcxjkg.com/content/5/8/970.short 4100 -http：//www.qdcxjkg.com/content.com/content/5/8/970.fullJ1992 9月1日;5 AB-近年来，血小板激活因子（PAF）被强烈涉及参与哮喘的介体。在非心脏病受试者中，已证明雾化的PAF会导致支气管收缩。这种体内效应的机制尚不清楚。我们先前已经表明，PAF引起人类孤立的支气管的收缩，该支气管在患者之间以及来自同一患者的组织内的大小变化。为了检查收缩中这种变异性是由PAF诱导的组织内炎症或上皮细胞释放出来的可能性，我们检查了收缩反应对PAF与炎症或上皮细胞的存在之间的关系。我们研究了五名患者的八个组织。在八个组织中，有四个收缩，而四个没有收缩的paf（7 x 10（-7）m）。 After the contractile response to PAF had been assessed by observing changes in isometric tone in vitro, bronchial rings were examined histologically to enable the quantification of inflammatory cell numbers and intact epithelium. No significant correlation was observed between the magnitude of contractions and numbers of eosinophils, neutrophils, lymphocytes, plasma cells, total cells or percentage intact epithelium. We conclude that it is unlikely that the variability in response to PAF in human isolated airways is related to the variability in inflammatory cell numbers or to the presence of epithelium. Thus, the contraction induced by PAF is probably not mediated via the release of a secondary mediator from the particular cells examined in this study.