TY - JOUR T1:慢性阻塞性肺病所致肺动脉高压的血管和心脏反应性:评估各种氧气浓度JF -欧洲呼吸杂志》乔欧元和J SP - 525 LP - 530 - 10.1183 / 09031936.93.05050525六世- 5 - 5盟征收Saadjian AU - F Philip-Joet盟盟——Arnaud Y1 - 1992/05/01 UR - //www.qdcxjkg.com/content/5/5/525.abstract N2 -本工作的目的是评估vasoreactivity肺动脉高压患者的慢性阻塞性肺疾病有关。这是通过比较患者呼吸室内空气、低氧和高氧混合物时记录的血流动力学数据来完成的。我们估计了血管收缩在决定肺动脉高压水平中的作用。本研究纳入26例继发于慢性阻塞性肺病(COLD)的中度肺动脉高压患者，患者平均肺动脉压(MPAP) = 27.3 +/- 1.2 mmHg, 1秒用力呼气量(FEV1) = 0.95 +/- 0.13 l;动脉氧张力(PaO2) = 8.7 +/- 0.25 kPa)。在肺动脉和股动脉分别插入热稀释导管和插管后，分别随机给予含15、21、30和100%氧气的混合物20分钟。随着吸气氧分数(FIO2)的增加，MPAP的下降幅度相对小于心脏指数。在室内空气呼吸时心排血量最高，而低氧混合物并没有导致进一步增加。与仅通过心率调节心排血量的正常受试者不同，这些患者的血流动力学调节还涉及到每搏量。 Variations in MPAP and cardiac index were strongly correlated with arterial oxygen saturation (SaO2). The greatest variations were noted in the patients with the highest pulmonary hypertension. Under normoxic and hyperoxic condition the relationship between pulmonary artery driving pressure and cardiac index was linear and its slope steeper in patients having the highest pulmonary hypertension at steady-state.(ABSTRACT TRUNCATED AT 250 WORDS) ER -