@article {Zappala830作者= {Zappala, c . j .和Latsi, p . i和尼科尔森,a·g·科尔比,t . v .克莱默,d . Renzoni, e·a·Hansell, d·m·杜波依斯,r . m .和富国a .美国},title ={边际用力肺活量下降与一个贫穷的结果在特发性肺纤维化},体积= {35}= {4},在特发性肺纤维化(IPF)的治疗性研究中，肺功能测试(pft)显著改变的低患病率一直是一个主要的限制因素。188bet官网地址评估了IPF和纤维化非特异性间质性肺炎(NSIP)中pft边缘变化的预后价值。在活检证实的IPF (n = 84)和NSIP (n = 72)患者中，6个月时肺的强迫肺活量(FVC)和一氧化碳扩散能力(DL,CO)趋势被归类为显著(FVC \>10\%;DL,CO \>15\%)或{\textquotedblleft}边际{\textquotedblright} (FVC 5{\textendash}10\%;DL公司7.5 {\ textendash} 15 \ %)。比例风险分析和时间依赖的受术者工作特征方法被用来检验PFT对死亡率的趋势。IPF中，有22例(26\%)FVC明显下降，19例(23\%)轻微下降。FVC显著下降的患者死亡率更高(风险比(HR) 2.80, 95% CI 1.54{{textendash}5.06;p <0.001)和FVC轻度下降者(HR 2.31, 95% CI 1.19{\textendash}4.50; p = 0.01) than in those with stable disease. Progression-free survival was lower when the decline in FVC was marginal than in stable disease (HR 2.34, 95\% CI 1.19{\textendash}4.60; p = 0.01). Marginal changes in DL,CO in IPF and marginal changes in FVC and DL,CO in fibrotic NSIP did not provide useful prognostic information. Marginal change in FVC in IPF denotes a poor outcome. These findings are applicable to clinical practice and to the selection of patients with more progressive disease for therapeutic studies.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/35/4/830}, eprint = {//www.qdcxjkg.com/content/35/4/830.full.pdf}, journal = {European Respiratory Journal} }