％0期刊文章％a wensel，R。％a jilek，C.％adörr，M。％a francis，D。P.％a stadler，h.％a lange，t.％a blumberg，f.％a opitz，c。％a pfeifer，M。％a ewert，R。％t损害心脏自主神经控制与肺动脉高压中的疾病严重程度有关％d 2009％r 10.1183/09031936.00145708％J欧洲呼吸道％X肺动脉高压（PAH）导致慢性心力衰竭，这与交感神经的增加有关。这可能会对心脏自主神经控制产生不利影响。我们调查了PAH患者疾病严重程度的心脏自主神经活动的变化。在48例PAH患者中（中位世界卫生组织III类，肺动脉压52±14 mmHg，肺血管耐药1,202±718 dyn·S·cm -5，心脏指数2.0±0.8 L·min -1·Min -1·M -2）和41个对照，通过测量心率变异性（HRV）和压力反射灵敏度评估心脏自主神经活动。所有患者均接受了心肺运动测试（峰值氧气吸收峰值13.2±5.1 ml·kg -1·min -1，微小通风/二氧化碳的生产斜率47±16）。在PAH患者中，高频（239±64对563±167 ms2），低频（245±58 v和599±219 ms2）和非常低频带（510±149），HRV的光谱功率降低了（239±64对563±167 MS2）对1106±598 ms2；全p <0.05）。 Baroreflex sensitivity was also blunted (5.8±0.6 versus 13.9±1.2 ms·mmHg−1; p<0.01). The reduction in high-frequency (r = 0.3, p = 0.04) and low-frequency (r = 0.33, p = 0.02) spectral power and baroreflex sensitivity (r = 0.46, p<0.01) was related to the reduction in peak oxygen uptake. Patients with PAH have a marked alteration in cardiac autonomic control that is related to exercise capacity and may, therefore, serve as an additional marker of disease severity. %U //www.qdcxjkg.com/content/erj/34/4/895.full.pdf