TY - JOUR T1 -合并肺纤维化和肺气肿综合征患者的肺动脉高压JF -欧洲呼吸杂志JO - Eur Respir J SP - 105 LP - 111 DO - 10.1183/09031936.00038709 VL - 35 IS - 1 AU - Cottin, V. AU - Le Pavec, J. AU - Prévot, G. AU - Mal, H. AU - Humbert, M. AU - Simonneau, G. AU - Cordier, J- f。AU -， Y1 - 2010/01/01 UR - //www.qdcxjkg.com/content/35/1/105.abstract N2 -本研究旨在描述近期个体化合并肺纤维化和肺气肿综合征的肺动脉高压患者的血流动力学和生存特征。一项回顾性多中心研究对40例患者(38例男性;年龄68±9岁;39例吸烟者)合并肺纤维化和肺气肿，右心导管插管时肺动脉高压。呼吸困难为功能性II类占15%，III类占55%，IV类占30%。6 min步行距离为244±126 m。用力肺活量为86±18%，1秒用力呼气量为78±19%，一氧化碳扩散传递系数为28±16%。室内空气动脉血氧张力7.5±1.6 kPa(56±12 mmHg)。平均肺动脉压40±9 mmHg，心脏指数2.5±0.7 L·min−1·m−2，肺血管阻力521±205 dyn·s·cm−5。 1-yr survival was 60%. Higher pulmonary vascular resistance, higher heart rate, lower cardiac index and lower carbon monoxide diffusion transfer were associated with shorter survival. Patients with combined pulmonary fibrosis and emphysema syndrome and pulmonary hypertension confirmed by right heart catheterisation have a dismal prognosis despite moderately altered lung volumes and flows and moderately severe haemodynamic parameters. ER -