TY - JOUR T1 - Flow-independent nitric oxide parameters in infants with and without recurrent wheeze JF - European Respiratory Journal JO - Eur Respir J SP - 818 LP - 819 DO - 10.1183/09031936.00063508 VL - 32 IS - 3 AU - Turner, S. W. AU - Franklin, P. J. AU - Mutch, R. C. AU - Stick, S. M. Y1 - 2008/09/01 UR - //www.qdcxjkg.com/content/32/3/818.abstract N2 - To the Editors: Flow-independent nitric oxide parameters (FIPs) have given an insight into airway physiology and pathology in adults and children 1. Measurements of fractional exhaled nitric oxide (FeNO) are sensitive to respiratory symptoms and environmental exposures in infants 2, 3; therefore, it would be reasonable to hypothesise that FIPs could extend current understanding about airway pathology in early life. Measurements of FeNO at different expiratory flows are needed to estimate FIPs and, given the challenge in measuring FeNO in infants, it is not surprising that the FIP literature in infants is limited to a single study of five healthy individuals 4. We measured FeNO at 11 and 40 mL·s−1 in 14 infants with and without recurrent wheeze as part of a larger methodological study 5. We have reanalysed our data, derived FIPs, and present our results herein. The present study population included 14 … ER -