% 0期刊文章% Rabiller, A %洁,x %Hamid, A. %A Resten, A. %A Parent, F. %A Haque, R. %A Capron, F. %A Sitbon, O. %A Simonneau, G. %A Humbert, M. %T Occult alveolar haemorrhage in pulmonary veno-occlusive disease %D 2006 %R 10.1183/09031936.06.00054105 %J European Respiratory Journal %P 108-113 %V 27 %N 1 %X Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension that affects predominantly post-capillary pulmonary vessels. A major concern with PVOD is the poor response to available therapies and the risk of pulmonary oedema with continuous intravenous epoprostenol. The present authors hypothesised that alveolar haemorrhage may be a characteristic feature of pulmonary veno-occlusive disease, as compared with other forms of pulmonary arterial hypertension that predominantly involve pre-capillary pulmonary arteries. This paper reports a series of 19 patients with either PVOD (n = 8) or idiopathic pulmonary arterial hypertension (IPAH; n = 11) who underwent bronchoalveolar lavage. Cytological analyses were performed and differential counts were made on Perls-stained preparations. The Golde score was used to assess alveolar haemorrhage. As compared with IPAH, PVOD was characterised by a higher percentage of haemosiderin-laden macrophages (40±37 versus 3±6%), resulting in elevated Golde scores (81±88 versus 4±10). It was concluded that occult alveolar haemorrhage is a common feature of pulmonary veno-occlusive disease. Detecting occult alveolar haemorrhage may be of interest in the diagnostic approach of pulmonary veno-occlusive disease. %U //www.qdcxjkg.com/content/erj/27/1/108.full.pdf