TY -的T1 - < em > S < / em > -carboxymethylcysteine正常化气道反应敏感和挑战老鼠JF -欧洲呼吸杂志》乔欧元和J SP - 577 LP - 585 - 10.1183 / 09031936.05.00090304六世- 26 - 4盟武田k . AU - Miyahara联合国非盟——玉t . AU - Taube, c . AU - Balhorn a . AU - Dakhama a . AU -北村k . AU - Hirano a . AU - Tanimoto m . AU -盖尔芬德E. W. Y1 - 2005/10/01 UR - //www.qdcxjkg.com/content/26/4/577.abstract N2 - s -羧甲基半胱氨酸(S-CMC)已被用作呼吸系统疾病的粘液调节剂。然而，S-CMC对过敏性气道炎症的作用机制尚未明确。在本研究中，BALB/c小鼠最初对卵清蛋白(OVA)敏感和挑战，几周后再次挑战OVA(二次挑战)。S-CMC (5-100 mg·kg−1)从二次攻毒前2天开始给药，直到检测当天。小鼠在二次刺激后6小时出现气道高反应性(AHR)，支气管肺泡灌洗液(BAL)中中性粒细胞数量增加。二次攻毒72小时后，小鼠再次出现AHR，但BAL液中含有大量嗜酸性粒细胞。S-CMC处理可在6 h降低AHR和中性粒细胞增多，在72 h降低嗜酸性粒细胞增多和AHR。这些影响似乎与剂量有关。在72 h观察到，S-CMC可减少杯状细胞增生。 In BAL fluid, increased levels of interferon-γ, interleukin (IL)-12 and IL-10 and decreased levels of IL-5 and IL-13 were detected. In conclusion, the data indicate that S-carboxymethylcysteine is effective in reducing airway hyperresponsiveness and airway inflammation at two distinct phases of the response to the secondary allergen challenge in sensitised mice. ER -