TY - T1的气道反应性高渗盐水:剂量反应斜率或PD15吗?JF -欧洲呼吸杂志》乔欧元和J SP - 153 LP - 158 - 10.1183 / 09031936.04.00008004六世- 25 - 1 AU - de米尔,g . AU -标志,g . b . AU - de Jongste J . c . AU - Brunekreef b Y1 - 2005/01/01 UR - //www.qdcxjkg.com/content/25/1/153.abstract N2 -气道挑战测试结果与高渗盐水(HS)表示为剂量导致下降了15%在一秒用力呼气量(FEV1);PD15)。noncensored测量,如剂量反应的斜率(DRS),使哮喘的风险的评估对象与FEV1下降& lt; 15%。本研究的目的是评估气道反应之间的关系HS PD15或DRS,哮喘症状和嗜酸性粒细胞的炎症反应的标志。数据当前的喘息和气道反应获得了1107名儿童(年龄在8日至13日年)。血清血嗜酸性粒细胞和嗜酸性粒细胞阳离子蛋白(ECP)评估子集(n = 683和485年)。PD15评估如果FEV1下降≥15%,所有测试的DRS计算。构造图来可视化关系目前的喘息,血液嗜酸性粒细胞和血清ECP。优势比和斯皮尔曼相关系数计算量化这些关系。 Children with features of asthma had lower PD15 and higher DRS, and separation was most pronounced for DRS. Prevalence of current wheeze increased continuously over the entire range of DRS values. Blood eosinophils were significantly higher only for the highest values of DRS. In conclusion, the continuous relationship between airway responsiveness and asthma symptoms is in favour of a noncensored measure of airway responsiveness, such as the dose-response slope. ER -