@article {de Meer153，作者= {de Meer，G。和Marks，G。B.和De Jongste，J。C.和Brunekreef，B。}，title = {气道对高渗盐水的反应：剂量 - 反应斜率或PD15？}，体积= ={25}，number = {1}，pages = {153--158}，年= {2005}，doi = {10.1183/09031936.04.0044004}，publisher = {欧洲呼吸社会}，摘要188bet官网地址= {高渗盐水（HS）的挑战测试表示为剂量，导致15 \％在一秒钟内强迫呼气量下降（FEV1； PD15）。一种未经验证的度量，例如剂量反应斜率（DRS），可以评估FEV1 \ <15 \％下降的受试者哮喘的风险。这项研究的目的是评估PD15或DRS，哮喘症状和嗜酸性粒细胞炎症标志物对HS的响应能力之间的关系。获得了1,107名儿童（8岁{\ textendash} 13岁）的当前喘息和气道响应能力的数据。在亚群中评估血液嗜酸性粒细胞和血清嗜酸性粒细胞阳离子蛋白（ECP）（n = 683和485）。如果FEV1下降> = 15 \％，则评估了PD15，并计算出所有测试的DRS。构建图形以与当前的喘息，血液嗜酸性粒细胞和血清ECP可视化关系。计算赔率和Spearman {\ textquoteright}的相关系数以量化这些关系。 Children with features of asthma had lower PD15 and higher DRS, and separation was most pronounced for DRS. Prevalence of current wheeze increased continuously over the entire range of DRS values. Blood eosinophils were significantly higher only for the highest values of DRS. In conclusion, the continuous relationship between airway responsiveness and asthma symptoms is in favour of a noncensored measure of airway responsiveness, such as the dose-response slope.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/25/1/153}, eprint = {//www.qdcxjkg.com/content/25/1/153.full.pdf}, journal = {European Respiratory Journal} }