PT -期刊文章盟Boezen h . m . AU - VonkJ. M. AU - van der Zee, S. C. AU - Gerritsen, J. AU - Hoek, G. AU - Brunekreef, B. AU - Schouten, J. P. AU - Postma, D. S. TI - Susceptibility to air pollution in elderly males and females AID - 10.1183/09031936.05.00076104 DP - 2005 Jun 01 TA - European Respiratory Journal PG - 1018--1024 VI - 25 IP - 6 4099 - //www.qdcxjkg.com/content/25/6/1018.short 4100 - //www.qdcxjkg.com/content/25/6/1018.full SO - Eur Respir J2005 Jun 01; 25 AB - It is important to know which individuals in the general population have increased susceptibility to air pollution. The aim of this study was to identify susceptible subgroups by studying airways hyperresponsiveness (AHR), high total immunoglobulin (Ig)E and sex. Diary data on lower and upper respiratory symptoms (LRS and URS, respectively), cough, and morning and evening peak expiratory flow (PEF) were collected in 327 elderly patients (50–70 yrs) for a period of 3 months. Acute effects of particulate matter with a diameter <10 µm, black smoke, sulphur dioxide and nitrogen dioxide on symptoms and PEF were estimated using logistic regression. In total, 48 (14.7%) subjects had AHR+/IgE+, 112 (34.3%) had AHR−/IgE+, 42 (12.8%) had AHR+/IgE− and 125 (38.2%) had AHR−/IgE−. In the AHR+/IgE+ group, each 10 µg·m−3 increase in air pollution was associated with a significant increase in prevalence of URS (odds ratio ranging 1.03–1.19), cough (1.03–1.08) and fall in morning PEF (1.04–1.26). In the AHR+/IgE+ group, males responded predominantly with symptoms and females with a fall in morning PEF. In conclusion, elderly individuals with both airway hyperresponsiveness and high total immunoglobulin E are especially susceptible to air pollution. Identifying susceptible subgroups might enlarge insight into the actual mechanisms by which air pollution evokes specific modes of response.