％0期刊文章％A Pletz，M.W.R。％a ioanas，M。％a de roux，A.％a burkhardt，o。％a lode，H。％t减少了外周血中性粒细胞的自发性凋亡，COPD％D 2004％d 2004％d 2004％R 10.1183/09031936.0936.04.00089004％j欧洲呼吸杂志％p 532-537％v 23％n 4％x慢性阻塞性肺疾病（COPD）急性加重的主要特征是支气管树中活化的嗜中性粒细胞的积累。由于抑制自发性凋亡，可以通过增加迁移和/或长时间存活来解释这种现象。这项研究的目的是评估急性加重过程中COPD患者外周血中性粒细胞的凋亡行为。包括36例住院的COPD患者，患有急性加重和10名健康志愿者。入院，3-5天后和出院时获得血样。培养18小时后，基于膜联蛋白V -PE结合和核形态来测量分离的中性粒细胞的自发凋亡。入院时，与健康的志愿者相比，COPD患者的自发凋亡率明显降低（平均值±SD 31±13％对44±18％）。入院时凋亡中性粒细胞的平均百分比为31±13％，3-5天后39±15％，出院时47±18％。 There was a statistically significant difference between the rates of spontaneous apoptosis on the first day and at discharge. Neither forced expiratory volume in one second <35% predicted, smoking habit, corticosteroid therapy nor evidence of bacterial infection showed any influence on the spontaneous apopotosis in this study. In conclusion, during acute exacerbations of chronic obstructive pulmonary disease, neutrophil granulocytes show a reduced spontaneous apoptosis that increases progressively after treatment and clinical remission. This raises the question of the importance of neutrophil apoptosis in the development and resolution of exacerbations of chronic obstructive pulmonary disease. M.W.R. Pletz was supported by the German Research Foundation. M. Ioanas is a fellow of the Paul-Ehrlich-Gesellschaft 2002. %U //www.qdcxjkg.com/content/erj/23/4/532.full.pdf