TY -的T1 -基质金属蛋白酶在肺修复JF -欧洲呼吸杂志》乔和J SP - 36欧元LP - 38 s - 10.1183 / 09031936.03.00001203六世- 22 - 44增刊盟厕所公园Y1 - 2003/09/20 UR - //www.qdcxjkg.com/content/22/44_suppl/36s.abstract N2 -本文的目的是讨论当前函数的概念基质金属蛋白酶(MMPs),重点是正宗的底物的识别。关注matrilysin (MMP 7)应承担的,它演示了如何一个细胞外蛋白酶可以调节上皮细胞生物学的关键和常见的功能,即抵御微生物,re-epithelialisation损伤和急性炎症反应。利用从急性肺损伤模型,发现matrilysin机制的行动在这些过程中,也就是说,它的作用在促进特定的蛋白质生物过程进行了探讨。尽管他们专业化服务不同的功能,不同组织的上皮反应类似于由等效损伤和感染和调节炎症机制。通过形成一个屏障和释放抗菌产品,上皮细胞提供对入侵病原体的第一道防线。受伤后,上皮细胞发起一系列程序的协调响应恢复组织的完整性。生产化学引诱物,粘附分子,和其他蛋白质,上皮细胞招募和限制炎性细胞的损伤。虽然看似发散过程,上皮计划调节修复,国防和炎症可能共同演进,特别是对选择性地诱导的基因。毕竟,损伤提供了一个机会感染,这可能导致伤害;这两个事件促炎。 Hence, many of the epithelial products associated with any one of these events are likely common to all. Matrilysin (MMP‐7), is an example of a protein that functions in defence, repair, and as shown here, inflammation. MMPs comprise a family of 23 (currently) related, yet distinct enzymes. MMPs are secreted or anchored to the cell surface 1, 2, thereby confining their catalytic activity to membrane proteins or proteins within the secretory pathway or extracellular space. As their name suggests, MMPs are thought to be responsible for the turnover and degradation of connective … ER -