％0刊期刊文章％A Petrek，M.％A Kolek，V.％ASzotkowská，J.％A Du Bois，R.M.％T CC和C趋化因子表达肺酸性症百分比％D 2002％R 10.1183 / 09031936.02.00289902％J欧洲呼吸期轴颈％P 1206-1212％V 20％N 5％x趋化因子咆哮（在激活上调节T细胞和分泌; CC趋化因子配体（CCL）-5）和单核细胞炎性蛋白（MIP）-1α（CCL-3）涉及肺结结病的肺泡炎的发育。新型C趋化因子单半胱氨酸基序（SCM）-1α（XCl-1）和CC趋化因子单核细胞化学蛋白（MCCH）-1（CCL-2）也是单核 - 细胞引诱剂，并且代表牙脉炎的替代候选候选者。因此，研究了MCP-1和SCM-1α的表达以及来自对照对象和患者的支气管肺泡灌洗液（BALF）的rantes和MIP-1α表达了rantes和MIP-1α。还探讨了趋化因子表达与结节病的关系。所有四个趋化因子的信使核糖核核酸（mRNA）表达通过从未分钝的支气管葡萄球菌（17名患者，12例对照）提取的RNA的半定位逆转录酶 - 聚合酶链反应来确定。通过酶联的BALF（60名患者，17例，对照）通过酶联免疫测定法测量RANTES，MIP-1α和MCP-1蛋白。在结节病中，MCP-1和即咆哮和SCM-1αmRNA表达，特别是患有更晚期疾病的患者。rantes，即MCP-1浓度在患者获得的BALF样品中升高; MCP-1 levels were most increased in patients with chest radiographic stage 2 disease and also in patients with persistent and recurrent disease. In conclusion, chemokines monocyte chemotactive protein-1 and single cysteine motif-1α are, in addition to RANTES, associated with the development of alveolitis in sarcoidosis and their expression parallels the disease course. This study was supported by the Czech Ministries of Health (IGA 3768-3) and of Schools, Education and Physical Training (MSM 151100002). %U //www.qdcxjkg.com/content/erj/20/5/1206.full.pdf