PT -期刊文章盟J.A.巴贝拉盟造成Peinado AU - s桑托斯TI -肺动脉高压的慢性阻塞性肺病援助- 10.1183 / 09031936.03.00115402 DP - 2003年5月01 TA -欧洲呼吸杂志》第六PG - 892 - 905 - 21 IP - 5 4099 - //www.qdcxjkg.com/content/21/5/892.short 4100 - //www.qdcxjkg.com/content/21/5/892.full所以欧元和J2003可能01;21 AB -肺动脉高压是一种常见的并发症的慢性阻塞性肺疾病(COPD)。它的存在与短生存和糟糕的临床演变。在慢性阻塞性肺病、肺高血压往往是温和的严重程度和进展缓慢。然而,短暂的发作期间可能发生肺动脉压力增加,运动和睡眠。右心室功能只是轻微受损,保护心脏的输出。肺循环的结构和功能变化已经显现在慢性阻塞性肺病的初始阶段。最近的调查表明内皮功能障碍和endothelium-derived介质的表达变化,调节血管张力和细胞生长的肺动脉轻度患者的疾病。其中的一些变化也存在于吸烟者肺功能正常。因此,它被假定初始事件的自然历史在慢性阻塞性肺病肺动脉高压可以由吸烟肺内皮的损伤产品。 Long-term oxygen administration is the only treatment that slows down the progression of pulmonary hypertension in chronic obstructive pulmonary disease. Nevertheless, with this treatment pulmonary artery pressure rarely returns to normal values and the structural abnormalities of pulmonary vessels remain unaltered. Vasodilators are not recommended on the basis of their minimal clinical efficacy and because they impair pulmonary gas exchange. Recognition of the role of endothelial dysfunction in the physiopathology of pulmonary hypertension in chronic obstructive pulmonary disease opens new perspectives for the treatment of this complication. The authors have been supported, in part, by research grants from Fondo de Investigación Sanitaria (FIS), Sociedad Española de Neumología y Cirugía Torácica (SEPAR), and Societat Catalana de Pneumologia (SOCAP).