Ty- Jour T1-睡眠呼吸暂停/呼吸症综合征患者的RR间隔的光谱振荡JF-欧洲呼吸杂志JO -EUR RESSIR J SP -943 LP -943 LP -950 do -10.1183/09031936.03.000936.03.00098002 vl -22 vl -22K. au -Assimakopoulos，T。Au -Wraith，P.K。au -fietze，I。au -witt，C.Au -Douglas，N.J。Y1- 2003/2003/12/01 Ur -http：//www.qdcxjkg.com/content/content/22/6/943.abstract-已经表明，在阻塞性睡眠呼吸暂停/呼吸症综合征（OSAHS）患者中，白天心率变异性降低。在本研究中，假设是OSAHS患者的呼吸暂停/呼吸症和夜间自主性活动周围的交感神经平衡发生了改变。进行RR间隔的频率和时间域分析，以无创监测交感神经活动。14名未经治疗的OSAHS患者和7名健康受试者进行了一夜之间的多摄影术。与未受干扰的睡眠相比，低（LF）和总（TF）频率功率在呼吸暂停（LF 229±38 ms2，TF 345±45 ms2）附近增加了2分钟（LF 106±18 ms2，TF 203±23 MS2）。高频（HF）功率的增加并不显着。LF的增加比不受干扰的睡眠（LFN 52±2个单位，HFN 48±2个单位）相比，比HF的增加（归一化LF（LFN）67±1个单位，标准化HF（HFN）33±1个单位）。 RR duration did not change around apnoeas/hypopnoeas (RR 904±28 ms). The LF and TF power increase was greater around arousal-inducing (LF 260±45 ms2, TF 390±65 ms2) compared with self-terminating (LF 161±31 ms2, TF 249±40 ms2) apnoeas/hypopnoeas; the LF and LFn increases were significant in both groups compared with undisturbed sleep and HF power differences were nonsignificant. RR intervals were longer around self-terminating apnoeas/hypopnoeas (RR 914±29 ms); the differences were not significant compared with undisturbed sleep. RR interval spectral power was not influenced by the event type. RR duration decreased (912±28 ms) and LF, HF and TF power increased (LF 111±16 ms2, HF 62±6 ms2, TF 173±21 ms2) across patients, compared with healthy controls (RR 1138±91 ms, LF 57±3 ms2, HF 35±3 ms2, TF 91±6 ms2). LFn and HFn did not change significantly. Sympathetic activity increases around apnoeas/hypopnoeas. The recurrent nocturnal fluctuations of sympathovagal balance and the overall increase of nocturnal autonomic activity may be of importance in the development of cardiovascular disease in sleep apnoea patients. K. Dingli was supported by a Research Fellowship from the European Respiratory Society. ER -