ty -jour t1-囊性纤维化肺中 ¹⁸ 氟脱氧葡萄糖的吸收：肺部炎症的量度？JF-欧洲呼吸杂志JO -EUR RESSIR J SP -848 LP -854 DO -10.1183/09031936.03.00065102 VL -21 IS -5 AU -LABIRIS，N.R。Au -Nahmias，C.Au -Freitag，A.P。Au -Thompson，M.L。Au -Dolovich，M.B。Y1-2003/05/01 UR -http：//www.qdcxjkg.com/content/21/5/848.abstract N2-正电子发射断层扫描是一种三维成像技术，可测量包括代谢在内的生理影响。18氟脱氧葡萄糖已被广泛用作大脑和肿瘤检测中细胞能代谢的示踪剂。由于中性粒细胞在呼吸道破裂过程中利用葡萄糖作为能源，因此假设这些细胞的18氟脱氧葡萄糖的摄取可以解释为囊性纤维化（CF）中嗜中性粒细胞活化的量度。10名成年CF患者接受了18氟脱氧葡萄糖的静脉注射推注，然后进行了90分钟的动态中肺采集扫描。使用patlak图评估了右肺18氟脱氧葡萄糖的摄取，并将值转换为葡萄糖利用率。三名临床上无效的肺结节病患者用作对照。 From the 10 CF patients with baseline sputum neutrophils of 14×106 cells·mL−1 who were investigated, seven were found to have sputum at a normal or slightly depressed glucose utilisation rate (mean 1.33 µmol·g−1·h−1) compared with a mean of 2.82 µmol·g−1·h−1 for the sarcoidosis patients. In eight patients, receiving inhaled tobramycin therapy, no change in lung glucose utilisation or sputum neutrophil counts were found. Despite high-sputum neutrophil levels, lung glucose utilisation was not elevated in patients with cystic fibrosis. This study was funded by the Canadian Cystic Fibrosis Foundation (SPARX 2). ER -