@Article {Newhouse816，作者= {Newhouse，M.T。和Patel，P。和Parry-billings，M。}，title = {防止甲基苯胺诱导的支气管痉挛：Salbutamol pmdi versclickhaler {\ textregistered} dpi}，音量= {21}816--820}，年= {2003}，doi = {10.1183/09031936.03.00045902}，Publisher = {欧洲呼吸社会}188bet官网地址，摘要= {无源干式吸入器（DPIS）已被开发为替代加压的介绍- 剂量吸入器（PMDIS）以改善吸入时的气溶胶输送并消除了对推进剂的需求。但是，与常规PMDI疗法相比，必须严格地将仿制药的新DPI配方进行。这项随机，双盲，双重，安慰剂对照，七向跨界研究评估了甲乙醇琳挑战的支气管牙挑战，以比较一个新颖的Salbutamol dpi（Clickhaler {clickhaler {\ textregistered}）与参考的Salbutamolpmdi（ventolimolin {\ textrolin {\ textregertered {}）。成年气道哮喘患者对甲基苯胺的过度反应性（促成性浓度浓度为20 \％，在一秒钟内强制呼气量下降（PC20）\ <4 mg {\ textperiodeDcentered} ml-1）在单独的天数处理0，0，100、200或400 {\ textmu} g Salbutamol通过DPI或PMDI。在沙丁胺醇治疗之前和之后，进行了甲基苯胺挑战，并通过Finney {\ textquoteright}的生物测定法分析了PC20比率，以测试吸入器的治疗等效性。18名患者完成了这项研究，并显示出对沙丁胺醇的显着剂量相关反应。DPI：PMDI的相对效力为1.29（90 \％置信区间1.04 {\ textendash} 1.63）。 There were no treatment differences in safety (cardiac frequency, blood pressure, adverse events). Methacholine-challenge methodology provides a sensitive bioassay and has demonstrated therapeutic equivalence of the salbutamol Clickhaler{\textregistered} dry-powder inhaler with the conventional salbutamol pressurised metered-dose inhaler. This study was supported by Innovata Biomed Ltd.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/21/5/816}, eprint = {//www.qdcxjkg.com/content/21/5/816.full.pdf}, journal = {European Respiratory Journal} }