Ty -jour t1-甲基蓝色减少内毒素绵羊JF中的肺水肿和环氧酶产物 - 欧洲呼吸杂志JO -EUR RESSIR J SP -957 LP -957 LP -964 DO -10.1183/09031936.02.02.00932001 VL- 20，O.V。Au -Evgenov，N.V。Au -Mollnes，T.E。au -bjertnaes，L.J。Y1 - 2002/10/01 Ur -http：//www.qdcxjkg.com/content/20/4/957.abstract N2-作者最近证明了甲基蓝（MB）一氧化氮（NO）途径可降低内毒素绵羊中肺毛细管压力，肺淋巴流量和蛋白质清除的增量。在本研究中，作者研究了MB是否通过除非途径以外的机制影响肺血流动力学和血管外肺水（EVLW）的积累。16例清醒，长期蒙文件的绵羊随机接收静脉注射10 mg·Kg-1或等渗盐水。30分钟后，所有绵羊都接受了大肠杆菌内毒素1 µg·Kg -1的静脉注射20分钟，然后静脉输注MB 2.5 mg·Kg -1·H -1或异托型盐。MB明显减弱了内毒素诱导的肺动脉高压和右心室衰竭，并减少了EVLW的积累。此外，MB降低了血浆血栓烷B2和6-酮 - 前甘酸素F1α的增量，并消除了发热反应。但是，MB对循环中性粒细胞，血清透明质酸和替代补体途径的总溶血活性没有影响。 The authors conclude that in sheep, methylene blue attenuates the endotoxin-induced pulmonary hypertension and oedema, at least in part, by inhibiting the cyclo-oxygenase products of arachidonic acid. This is a novel effect of methylene blue in vivo. This study was supported in part by the Research Council of Norway (grant 120473/730), the Laerdal Foundation for Acute Medicine, and departmental funds. ER -