@article {evgenov957，作者= {evgenov，o.v。以及N.V. Evgenov和T.E. Mollnes和bjertnaes，l.j。}，title = {亚甲基蓝色减少内毒素绵羊中的肺水肿和环氧酶产物，体积= {20}，number = {4}，pages = {957---964}，年= {2002}，earl = {2002}，doi = {10.1183/09031936.02.00932001}，Publisher = {欧洲188bet官网地址呼吸社会}，摘要= {作者最近证明了亚氮（NO）途径的甲基蓝（MB），减少了肺化合物的增量内毒素绵羊的压力，肺淋巴流量和蛋白质清除率。在本研究中，作者研究了MB是否通过除非途径以外的机制影响肺血流动力学和血管外肺水（EVLW）的积累。16个醒着，长期蒙上的绵羊随机接收了静脉注射10 mg {\ textperiodeDectreed} kg-1或等渗盐水。三十分钟后，所有绵羊都会静脉注射大肠杆菌内毒素1 {\ textmu} g {\ textperiodcentered} kg-1 kg-1 kg-1持续20分钟，然后静脉输注Mb 2.5 mg {\ textperidpericentered} kg-1 {\ textpericentered} kg-1 {H-1或等渗盐水持续6小时。MB明显减弱了内毒素诱导的肺动脉高压和右心室衰竭，并减少了EVLW的积累。此外，MB降低了血浆血栓烷B2和6-酮 - 前甘酸素F1α的增量，并消除了发热反应。 However, MB had no effect on the changes in circulating neutrophils, serum hyaluronan, and total haemolytic activity of the alternative complement pathway. The authors conclude that in sheep, methylene blue attenuates the endotoxin-induced pulmonary hypertension and oedema, at least in part, by inhibiting the cyclo-oxygenase products of arachidonic acid. This is a novel effect of methylene blue in vivo. This study was supported in part by the Research Council of Norway (grant 120473/730), the Laerdal Foundation for Acute Medicine, and departmental funds.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/20/4/957}, eprint = {//www.qdcxjkg.com/content/20/4/957.full.pdf}, journal = {European Respiratory Journal} }