@article {admyre578，作者= {Admyre，C。和Grunewald，J。和Thyberg，J。和Gripenb {\“ A} Ck，S。和Tornling，G。和Eklund，A。和Scheynius，A。A.和Gabrielsson，，S。}，title = {具有主要组织相容性复杂的II类和共同刺激分子的外泌体中存在于人类BAL液体中，体积= {22}，number = {4}，页面= {578--583}，年，年= {2003}，doi = {10.1183/09031936.03.00041703}，Publisher = {欧洲188bet官网地址呼吸社会}，摘要= {exosomes是30 {\ textEndEndash} 100 nm直径囊，由几个细胞和几个细胞形成的细胞形成，并形成。来自DCS的T-Cells，B细胞和树突状细胞（DC）的类型来自DCS的外泌体表达主要的组织相容性复合物（MHC）I类和II类，以及表面上的共刺激分子，并可以诱导抗原特异性的激活T细胞。本研究的目的是调查健康个体的支气管肺泡灌洗液（BALF）中的外泌体，并确定如果这些外泌体带有MHC和共刺激分子。作者分析了从七名健康志愿者那里获得的BALF，并从单核细胞来源的DC（MDDC）培养物中使用了外泌体作为参考。超速离心后，外泌体与抗MHC II类涂层磁珠结合，并通过流式细胞仪和电子显微镜进行分析。作者首次报告说外泌体存在于BALF中。这些外泌体类似于MDDC衍生的外泌体，因为它们表达了MHC I和II，CD54，CD63和共刺激分子CD86。 The results demonstrate that exosomes are present in the lung, and since they contain both major histocompatibility complex and co-stimulatory molecules it is likely that they are derived from antigen presenting cells and might have a regulatory role in local immune defence. This work was supported by the Swedish Research Council (grants no. 16x-7924, 74x-14182, and 6537), the Swedish Council for Work Life Sciences, the Swedish Asthma and Allergy Association{\textquoteright}s Research Foundation, the Hesselman Foundation, Konsul TH Bergs Foundation, the Swedish Heart-Lung Foundation, the V{\r a}rdal Foundation, the Centre for Allergy Research at Karolinska Institutet, the King Oscar II Jubilee Foundation, the King Gustaf V 80th Birthday Fund and the Karolinska Institutet.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/22/4/578}, eprint = {//www.qdcxjkg.com/content/22/4/578.full.pdf}, journal = {European Respiratory Journal} }