TY - T1的一氧化碳coefficien转移t (transfer factor/alveolar volume) in females versus males JF - European Respiratory Journal JO - Eur Respir J SP - 186 LP - 187 DO - 10.1183/09031936.03.00024903 VL - 22 IS - 1 AU - Hughes, J.M.B. AU - Pride, N.B. Y1 - 2003/07/01 UR - //www.qdcxjkg.com/content/22/1/186.abstract N2 - To the Editors: The single breath transfer factor of the lung for carbon monoxide (TL,CO) is derived from the multiple of the carbon monoxide transfer coefficient (KCO) and the alveolar volume (VA) during breath holding 1; consequently, the TL,CO is highly dependent on lung size (∼VA), and thus is smaller in females for a given height and age. Essentially, the KCO is the rate constant for alveolar carbon monoxide uptake (its units are per second or per minute) and may be expected to be the same in males as in females, as it was in the original description of the technique 2. The published guidelines 3, 4 are not definitive on this point, so we reviewed all studies of reference values for TL,CO and KCO, which have presented data for both males and females. The European reference values for KCO 3 are derived from the ratio TL,CO predicted/total lung capacity (TLC) predicted. This unusual recommendation arose from correspondence in the ERJ 5, which pointed … ER -