% 0期刊文章% Sadeghi-Hashjin, g . % Nijkamp, F.P. %甘伟鸿,P.A.J. % Folkerts, g . % T cromoglycate钠和doxantrazole氧气激进的食腐动物% D R 10.1183 / 2002% 09031936.02.00382002 % % P J欧洲呼吸杂志》867 - 872 V % 20% 4% N X的影响两个柱状细胞稳定器,钠cromoglycate (SCG)和doxantrazole,研究了活性氧(ROS)的形成。豚鼠肺泡巨噬细胞(AMs)产生lucigenin依赖的化学发光(LDCL)。当用福波肉豆蔻酸酯(PMA)或酵素(在60分钟的LDCL总量中分别增加了133%和464%)刺激细胞时，这种反应增加。SCG降低pma诱导的LDCL浓度(10 mM，降低55%)高于doxantrazole (1 mM，降低75%)。SCG降低了AMs对酵素的自由基生成，且呈浓度依赖性，降低幅度≤72%。Doxantrazole (0.1-1 mM)使总LDCL减少30-80%。此外，葡萄糖氧化酶在无细胞培养基中与葡萄糖共孵育可导致LDCL的产生。在SCG或doxantrazole存在时，抑制率为47-83%。SCG和doxantrazole对过氧化氢和过氧亚硝酸盐诱导的LDCL的抑制率≤92%。 Moreover, these drugs slightly increased the survival rate of the AMs. It is concluded that doxantrazole- and sodium cromoglycate-inhibited lucigenin-dependent chemiluminescence production by guinea-pig alveolar macrophages is due to a direct scavenging effect on reactive oxygen species. Doxantrazole is ∼10-times more potent. Mast cell stabilisers may be effective in allergic asthma not only by preventing the allergen-induced mediator release, but also by preventing radical-induced lung damage. %U //www.qdcxjkg.com/content/erj/20/4/867.full.pdf