TY -的T1 -钠cromoglycate和doxantrazole氧气激进的食腐动物JF -欧洲呼吸杂志》乔欧元和J SP - 867 LP - 872 - 10.1183 / 09031936.02.00382002六世- 20 - 4盟Sadeghi-Hashjin g . AU - Nijkamp F.P.盟——甘伟鸿P.A.J.盟——Folkerts g . Y1 - 2002/10/01 UR - //www.qdcxjkg.com/content/20/4/867.abstract N2 -两个肥大细胞稳定机制的影响,钠cromoglycate (SCG)和doxantrazole,形成的活性氧(ROS)进行了研究。豚鼠肺泡巨噬细胞(AMs)生成lucigenin-dependent化学发光(LDCL)。这是十四烷酸细胞刺激时增加了佛波醇酯(PMA)或酵母聚糖(分别为133%和464%,在总LDCL超过60分钟)。SCG减少PMA-induced LDCL更高浓度(10毫米,55%)比doxantrazole(1毫米,75%)。SCG激进生产降低了AMs在应对酵母聚糖浓度≤72%。Doxantrazole(0.1 - 1毫米)减少总LDCL 30 - 80%。此外,葡萄糖氧化酶导致LDCL代读与葡萄糖在孵化时的介质。这是抑制了47 - 83%的SCG或doxantrazole。SCG doxantrazole抑制过氧化氢-和peroxynitrite-induced LDCL≤92%。此外,这些药物稍微增加了AMs的存活率。 It is concluded that doxantrazole- and sodium cromoglycate-inhibited lucigenin-dependent chemiluminescence production by guinea-pig alveolar macrophages is due to a direct scavenging effect on reactive oxygen species. Doxantrazole is ∼10-times more potent. Mast cell stabilisers may be effective in allergic asthma not only by preventing the allergen-induced mediator release, but also by preventing radical-induced lung damage. ER -