TY - JOUR T1 -夜间症状哮喘患者肺泡一氧化氮浓度升高JF -欧洲呼吸杂志JO - Eur Respir J SP - 841 LP - 845 DO - 10.1183/09031936.02.00202002 VL - 20 IS - 4 AU - Lehtimäki, L. AU - Kankaanranta, H. AU - Saarelainen, S. AU - Turjanmaa, V. AU - Moilanen，E. Y1 - 2002/10/01 UR - //www.qdcxjkg.com/content/20/4/841.abstract N2 -夜间哮喘症状和夜间肺功能受损与肺外周室的炎症活动有关。呼气一氧化氮(NO)在多个呼气流速下的测量可用于单独评估肺泡和支气管的NO生成和炎症。作者假设有夜间症状的哮喘患者的肺泡NO浓度高于只有白天症状的患者。作者通过使用书面问卷，询问了40名新诊断为steroid-naïve哮喘的患者关于他们的夜间哮喘症状。评估了40例哮喘患者和40例健康对照组的肺泡NO浓度和支气管NO通量。40例患者中有19例报告有夜间症状。有夜间症状的患者肺泡NO浓度(1.7±0.3 (mean±sem) ppb)高于无夜间症状的患者(0.8±0.3 ppb, p=0.012)或健康对照组(1.0±0.1 ppb, p=0.032)。夜间症状有(2.4±0.4 nL·s−1,p<0.001)和无(2.6±0.4 nL·s−1,p<0.001)的患者的支气管NO通量均高于对照组(0.7±0.1 nL·s−1)。哮喘患者夜间症状与较高的肺泡一氧化氮浓度有关。 The results suggest that assessment of alveolar nitric oxide concentration can be used to detect the parenchymal inflammation in asthmatic patients with nocturnal symptoms. The study was supported by grants from the National Technology Agency (Tekes), the Medical Research Fund of Tampere University Hospital, Tampere Tuberculosis Foundation, Jalmari and Rauha Ahokas Foundation, and the Academy of Finland. ER -