RT Journal Article SR Electronic T1 Prone position in acute respiratory distress syndrome JF European respiratory Journal JO Eur Respir J FD 188bet官网地址European respiratory Society SP 1017 OP 1028 DO 10.1183/09031936.02.00401702 VO 20 IS 4在过去的几年里，俯卧位越来越多地被用于治疗急性呼吸窘迫综合征(ARDS)患者，这种姿势现在被认为是一种简单和安全的改善氧合的方法。然而，引起呼吸功能改善的生理机制以及真正的临床益处尚不完全清楚。这篇综述的目的是讨论俯卧位在ARDS患者中的生理和临床效果。俯卧位的主要生理目的是:1)改善氧合;2)改善呼吸力学;3)均匀化胸膜压力梯度、肺泡充气和通气分布;4)增加肺容量，减少肺不张区;5)便于分泌物排出;6)减少呼吸机相关肺损伤。 According to the available data, the authors conclude that: 1) oxygenation improves in ∼70–80% of patients with early acute respiratory distress syndrome; 2) the beneficial effects of oxygenation reduce after 1 week of mechanical ventilation; 3) the aetiology of acute respiratory distress syndrome may markedly affect the response to prone positioning; 4) extreme care is necessary when the manoeuvre is performed; 5) pressure sores are frequent and related to the number of pronations; 6) the supports used to prone and during positioning are different and nonstandardised among centres; and 7) intensive care unit and hospital stay and mortality still remain high despite prone positioning.