Ty-Jour T1 - 急性呼吸窘迫综合征JF - 欧洲呼吸杂志Jo - Eur Respir J SP - 1017 LP - 1028 Do - 10.1183 / 09031936.02.00401902 VL - 20是 - 4 Au - 佩洛西，P. Au - Brazzi，L. Au - Gattinoni，L. Y1 - 2002/10/01 UR - //www.qdcxjkg.com/content/20/4/1017.Abstract n2 - 在过去几年中，越来越多的定位已经越来越多地使用在治疗急性呼吸窘迫综合征（ARDS）的患者中，这种操纵现在被认为是一种简单而安全的方法来改善氧合。然而，尚未完全理解导致呼吸功能改善的生理机制以及真正的临床效益。本综述的目的是讨论ARDS患者易受定位的生理和临床影响。易于定位的主要生理目标是：1）改善氧合;2）改善呼吸力学;3）使胸膜压力梯度均匀，肺泡通胀和通风分布;4）增加肺部体积并减少房地产区域的数量;5）促进分泌物的排水;6）减少呼吸机相关的肺损伤。 According to the available data, the authors conclude that: 1) oxygenation improves in ∼70–80% of patients with early acute respiratory distress syndrome; 2) the beneficial effects of oxygenation reduce after 1 week of mechanical ventilation; 3) the aetiology of acute respiratory distress syndrome may markedly affect the response to prone positioning; 4) extreme care is necessary when the manoeuvre is performed; 5) pressure sores are frequent and related to the number of pronations; 6) the supports used to prone and during positioning are different and nonstandardised among centres; and 7) intensive care unit and hospital stay and mortality still remain high despite prone positioning. ER -