RT期刊文章SR电子T1血浆TARC浓度可能是儿童哮喘加重的有用标志物JF欧洲呼吸杂志JO Eur Respir J FD欧洲呼吸学会SP 616 OP 620 DO 10.1183/09031936.03.00083303 VO 21 IS 4 A1 Leung, T.F. A1 Wong, C.K. A1 Lam, C.W.K. A1 Li, 188bet官网地址A.M.A1 Ip, w.k.a1 Wong, g.w.k.a1 Fok, T.F. YR 2003 UL //www.qdcxjkg.com/content/21/4/616.abstract AB最近的研究表明t辅助细胞-2型淋巴细胞特异性胸腺和活化调节趋化因子(TARC)和单核细胞来源的趋化因子(MDC)是慢性哮喘有用的炎症标志物。然而，它们在评估急性哮喘严重程度方面的作用尚不清楚。本研究旨在评价哮喘加重患儿血浆TARC和MDC浓度的序列变化。所有急性哮喘患者均给予全身性皮质类固醇治疗5天。哮喘加重的严重程度根据全球哮喘倡议指南进行分类。采用夹心酶免疫法测定血浆TARC和MDC浓度。研究招募了16名中位年龄9.3(7.2-10.6)岁且哮喘加重的儿童。血浆TARC浓度与呼气流速峰值呈负相关。与治疗后1周(31 pg·mL−1)和5周(32 pg·mL−1)的水平相比，急性发作期间的中位血浆TARC浓度最高(46 pg·mL−1)。 The median plasma MDC level similarly decreased from 698 pg·mL−1 at baseline to 261 pg·mL−1 1 week later, but increased back to 574 pg·mL−1 at 5 weeks. These results suggest that plasma T-helper cells type-2 lymphocytes-specific thymus and activation-regulated chemokine but not monocyte-derived chemokine concentration may be a useful inflammatory marker in assessing asthmatic exacerbation in children.