TY - T1的吸气神经驱动缺氧反应充分估计外围化学敏感性低患者JF -欧洲呼吸杂志》乔欧元和J SP - 724 LP - 732 - 10.1183 / 09031936.02.00250102六世- 20 - 3盟Garcia-Rio f . AU -皮诺,J.M. AU -拉米雷斯,t . AU -阿尔瓦罗·d . AU -阿隆索,a . AU - VillasanteC. AU -维拉莫尔，j . Y1 - 2002/09/01 UR - //www.qdcxjkg.com/content/20/3/724.abstract N2 -本研究的目的是检查响应之间的关系进步isocapnic缺氧和缺氧退出测试在阻塞性睡眠apnoea-hypopnoea综合症患者(低)和分析颈动脉体的决定因素灵敏度低。选择19名OSAHS患者和13名健康受试者。测定呼吸(ΔV’i /Sa,O2/BSA)和吸气神经驱动(ΔP0.1/Sa,O2)对进行性等冠状动脉缺氧的反应。通过缺氧停药试验评估外周化疗敏感性，该试验测量两次100%氧气呼吸(%ΔV 'I)导致的通气减少。OSAHS患者对缺氧的戒断反应和呼吸和吸气神经驱动反应低于对照组。在OSAHS患者中，%ΔV’i与ΔV’i /Sa、O2/BSA、ΔP0.1/Sa、O2显著相关。多元线性逐步回归分析发现，%ΔV’i与ΔP0.1/Sa、O2有较强的相关性。 Moreover, %ΔV′I, ΔV′I/Sa,O2/BSA and ΔP0.1/Sa,O2 were significantly correlated with minimum arterial oxygen saturation and with arousal index. Obstructive sleep apnoea-hypopnoea syndrome patients have a strong relationship between peripheral chemosensitivity and respiratory response to hypoxia, suggesting that hypoxic stimulation of central chemoreceptors is minimally relevant in obstructive sleep apnoea-hypopnoea syndrome. Moreover, sensitivity of the carotid body in patients with obstructive sleep apnoea-hypopnoea syndrome is related to sleep disruption and to nocturnal hypoxia. This study was supported by FIS (96/1280 and 99/0252) and Neumomadrid (2000) Grants. ER -