TY - JOUR T1 - 缺氧吸气神经驱动响应充分估计OSAHS患者JF末梢化学敏感性 - 欧洲呼吸杂志JO - EUR呼吸杂志SP - 724 LP - 732 DO - 10.1183 / 09031936.02.00250102 VL - 20 - 3 AU - 加西亚-Río, F. AU - Pino, J.M. AU - Ramirez, T. AU - Alvaro, D. AU - Alonso, A. AU - Villasante, C. AU - Villamor, J. Y1 - 2002/09/01 UR - //www.qdcxjkg.com/content/20/3/724.abstract N2 - The aim of the present study was to examine the relationships between the responses to progressive isocapnic hypoxia and hypoxic withdrawal test in patients with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and to analyse the determinants of carotid body sensitivity in OSAHS. Nineteen consecutive OSAHS patients and 13 healthy subjects were selected. Ventilatory (ΔV′I/Sa,O2/BSA) and inspiratory neural drive (ΔP0.1/Sa,O2) responses to progressive isocapnic hypoxia were determined. Peripheral chemosensitivity was evaluated by the hypoxic withdrawal test, which measures the decrease in ventilation caused by two breaths of 100% oxygen (%ΔV′I). Withdrawal response and ventilatory and inspiratory neural drive responses to hypoxia were lower in OSAHS patients than in control subjects. In patients with OSAHS, %ΔV′I correlated significantly with ΔV′I/Sa,O2/BSA and with ΔP0.1/Sa,O2. On stepwise multiple linear regression analysis, a strong correlation between %ΔV′I and ΔP0.1/Sa,O2 was found. Moreover, %ΔV′I, ΔV′I/Sa,O2/BSA and ΔP0.1/Sa,O2 were significantly correlated with minimum arterial oxygen saturation and with arousal index. Obstructive sleep apnoea-hypopnoea syndrome patients have a strong relationship between peripheral chemosensitivity and respiratory response to hypoxia, suggesting that hypoxic stimulation of central chemoreceptors is minimally relevant in obstructive sleep apnoea-hypopnoea syndrome. Moreover, sensitivity of the carotid body in patients with obstructive sleep apnoea-hypopnoea syndrome is related to sleep disruption and to nocturnal hypoxia. This study was supported by FIS (96/1280 and 99/0252) and Neumomadrid (2000) Grants. ER -