慢性阻塞性肺疾病中体重变化的预后价值:结果从哥本哈根城市心脏研究援助- 10.1183 / 09031936.02.00532002 DP - 2002年9月01 TA -欧洲呼吸杂志》第六PG - 539 - 544 - 20的IP - 3 4099 - //www.qdcxjkg.com/content/20/3/539.short 4100 - //www.qdcxjkg.com/content/20/3/539.full所以欧元和J2002 9月01;20 AB—在慢性阻塞性肺疾病(COPD)患者中，低体重指数(BMI)与不良预后之间存在关联，许多研究已经发现。对未选择的COPD患者体重变化的患病率和预后重要性进行了检查。在哥本哈根城市心脏研究中，COPD的定义是一秒用力呼气量/用力肺活量为0.7，并分别参加了两次检查，间隔5年，对COPD相关和全因死亡率进行了14年的随访。两项检查中体重指数下降1个单位(~ 3.8 kg)的受试者比例与COPD水平显著相关，重度COPD患者的比例达到~ 30%。在调整了年龄、吸烟习惯、基线BMI和肺功能后，体重减轻与COPD患者和非COPD患者的较高死亡率相关(体重减轻和gt的比率比为1.71(95%可信区间(CI): 1.32-2.23)和1.63 (95% CI分别为1.38-1.92))。体重增加与死亡率增加相关，但在COPD患者中没有显著差异。copd相关死亡的风险随体重减轻而增加(RR 2.14 (95% CI 1.18-3.89))，但与体重增加无关(RR 0.95 (95% CI 0.43-2.08))。在无COPD或轻度至中度COPD的受试者中，不论初始体重如何，体重变化的影响是相同的。 In subjects with severe COPD, there was a significant risk ratio modification (p=0.045) between effect of baseline BMI and weight change: in the normal-to-underweight (BMI<25), best survival was seen in those who gained weight, whereas for the overweight and obese (BMI≥25), best survival was seen in stable weight. A high proportion of subjects with chronic obstructive pulmonary disease experienced a significant weight loss, which was associated with increased mortality. The results support further intervention studies that aim at avoiding weight loss in normal-to-underweight chronic obstructive pulmonary disease patients.