@article {Prescott539, author = {Prescott, E. and Almdal, T. and Mikkelsen, K.L. and Tofteng, C.L. and Vestbo, J. and Lange, P.}， title ={体重变化在慢性阻塞性肺病中的预后价值:结果来自哥本哈根城市心脏研究}，volume = {20}， number = {3}， pages ={539—544}，year = {2002}， doi = {10.1183/09031936.02.00532002}， publisher ={欧洲呼吸学会}，188bet官网地址多项研究发现，慢性阻塞性肺疾病(COPD)患者的低体重指数(BMI)与不良预后之间存在关联。对未选择的COPD患者体重变化的患病率和预后重要性进行了检查。COPD患者，在哥本哈根城市心脏研究中定义为一秒用力呼气量/用力肺活量<0.7，并分别参加两次检查，间隔5年，随访14年，观察COPD相关和全因死亡率。两项检查中体重指数(BMI)下降(>1单位(3.8 kg))的受试者比例与COPD水平显著相关，重度COPD患者的比例达到30 %。在调整了年龄、吸烟习惯、基线体重指数和肺功能,减肥与高死亡率在残疾人和没有慢性阻塞性肺病(率比(RR)减肥\ > 3 BMI单位1.71(95 \ %可信区间(CI): 1.32 {\ textendash} 2.23)和1.63 (95 \ % CI 1.38 {\ textendash} 1.92),分别)。体重增加与死亡率增加相关，但在COPD患者中没有显著差异。慢性阻塞性肺病相关死亡风险随体重减轻而增加(RR 2.14 (95\% CI 1.18{}3.89))，但随体重增加而增加(RR 0.95 (95\% CI 0.43{}2.08))。在无COPD或轻度至中度COPD的受试者中，不论初始体重如何，体重变化的影响是相同的。 In subjects with severe COPD, there was a significant risk ratio modification (p=0.045) between effect of baseline BMI and weight change: in the normal-to-underweight (BMI\<25), best survival was seen in those who gained weight, whereas for the overweight and obese (BMI>=25), best survival was seen in stable weight. A high proportion of subjects with chronic obstructive pulmonary disease experienced a significant weight loss, which was associated with increased mortality. The results support further intervention studies that aim at avoiding weight loss in normal-to-underweight chronic obstructive pulmonary disease patients.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/20/3/539}, eprint = {//www.qdcxjkg.com/content/20/3/539.full.pdf}, journal = {European Respiratory Journal} }